ethnopharmacology

/ethnopharmacology and gender differences, dr. tang
rec'd may 2006

pharmacokinetic issues
diet
Sudanese study regarding antipyrene
dosing
most recommendations based on majority population
metabolism
poor: practically no metabolism; nonworking or missing alleles/genes
slow: phenotypically mimics poor metabolizers
extensive = normal
ultra extensive: very efficient metabolism; may have multiple copies of gene

Cytochrome P450
2D6: metabolizes TCA
poor metabolizers: 5-7% Caucasians
2% African Americans
2% Hispanic
1% East Asian
slow metabolizers: up to 33% African Americans and Asians
ultra extensive: e.g. Spain natives have mutation that makes them fatst
2C19
poor metabolizers: Western population: 3%
3% African American
25% Asian American